China Medical University Welcomes Academician Hui-Kuan Lin for Global Exchange on Cancer Metabolism Research

On July 10, China Medical University welcomed Academician Hui-Kuan Lin, Distinguished Professor at Duke University School of Medicine and member of Academia Sinica, to deliver a keynote lecture titled “Warburg Effect: Signaling Metabolites in Cancer and Immune Regulation.”

Addressing more than 100 faculty members and graduate students, Academician Lin highlighted how cancer cells exploit metabolic reprogramming to evade immune surveillance. He explained that cancer cells preferentially utilize glycolysis even under oxygen-rich conditions—a phenomenon known as the Warburg effect. His research has further demonstrated that metabolites such as lactate and inositol act as signaling molecules that suppress innate immune responses, providing new insights into tumor progression and resistance to immunotherapy.

Academician Lin also shared recent discoveries published in Cell, Nature Cell Biology, and Cell Metabolism, including the identification of CD36 as a key receptor mediating the cellular uptake of PROTAC therapeutics. This breakthrough helps clarify the mechanism of drug entry into cells and provides new strategies for the development of next-generation cancer treatments.

Following the lecture, Academician Lin engaged in one-on-one research discussions with several China Medical University faculty members in cancer-related fields. The discussions focused on cancer metabolism, immune regulation, and future research directions, fostering academic exchange and strengthening collaborations between China Medical University and leading international research teams.

The visit highlighted the importance of interdisciplinary collaboration in advancing precision medicine and further enhanced China Medical University’s research capacity in cancer metabolism and immunotherapy.

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